GSE122041

syn77073020

Created By Aditya Nath aditya.nath

doi: 10.1158/0008-5472.CAN-19-3588
title: Gene expression profiles of isogenic single-cell derived clones of BRAF-mutated SK-MEL-5 melanoma cell lines
funder: NIH-NCI
series:
creator: Paudel Bishal Quaranta Vito
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9775651
subject: SK-MEL-5
ageGroup:
citation: Paudel BB et al. (2020). An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells. Cancer Res. 80(20):4565-4577. doi: 10.1158/0008-5472.CAN-19-3588
dataType: gene expression
keywords: Melanoma SK-MEL-5
accessType: Open Access
contributor:
description: We recently reported that single-cell derived isogenic subclones of SKMEL5 cells have differential initial sensitivity to BRAF-inhibitors. In order to probe differences among these subclones, we selected three subclones with unique drug responses: progressing (SK-MEL-5 SC10), stationary (SK-MEL-5 SC07), and regressing (SK-MEL-5 SC01) and performed RNASeq. This study examines differentially expressed genes (DEGs) among the subclones to identify the molecular basis for initial differences in dr...
grantNumber: CA215845
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE122041
manifestation:
specimenCount: 9
yearProcessed: 2018
countryOfOrigin:
individualCount: 9
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE122041
includedInDataCatalog:

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