GSE127988

syn77072655

Created By Aditya Nath aditya.nath

doi: 10.1016/j.cels.2020.10.002
title: Gene expression of the A375 melanoma cell line treated with RAF inhibitors Vemurafenib and time-course with EGF stimulation during Vemurafenib RAF inhibitor treatment alone or with the MEK inhibitor Cobimetinib
funder: NIH-NCI
series:
creator: Gerosa Luca
license: CC-BY 4.0
species: Homo sapiens
studyId: syn12051865
subject: A375 melanoma
ageGroup:
citation: Gerosa L et al. (2020). Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells. Cell Syst. 11(5):478-494.e9. doi: 10.1016/j.cels.2020.10.002
dataType: gene expression
keywords: A375 melanoma
accessType: Open Access
contributor:
description: We treated for 24 hours the BRAF-V600E melanoma cell line A375 with 7 doses of the RAF inhibitor Vemurafenib and, in a second experimental desing, we treated for 24 hours the BRAF-V600E melanoma cell line A375 with Vemurafenib (1 uM) alone or in combination with the MEK inhibitor Cobimetinib (1 uM) and subsequently stimulated with EGF in a time-course of 7 time points for up to 8 hours (0, 0.5, 1, 2, 3, 4, 8 hours).
grantNumber: CA225088
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE127988
manifestation:
specimenCount: 96
yearProcessed: 2019
countryOfOrigin:
individualCount: 96
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE127988
includedInDataCatalog:

GSE127988 page is loading…