GSE137069

syn77070407

Created By Aditya Nath aditya.nath

doi: 10.1038/s41586-020-03147-x
title: An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [scATAC-Seq]
funder: NIH-NCI
series:
creator: Alonso Curbelo Direna Lowe Scott
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315805
subject:
ageGroup:
citation: Alonso-Curbelo D et al. (2021). A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 590(7847):642-648. doi: 10.1038/s41586-020-03147-x
dataType: chromatin activity
keywords: pancreas
accessType: Open Access
contributor:
description: Damaged tissues have increased risk of cancer development through poorly understood mechanisms. For example, in the pancreas, tissue damage collaborates with activating mutations in the Kras oncogene to dramatically accelerate the formation of early neoplastic lesions and, ultimately, pancreatic cancer. By integrating genomics, single-cell chromatin assays and spatiotemporally-controlled functional perturbations in autochthonous tumor models, we show that the combination of Kras mutation and ...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE137069
manifestation:
specimenCount: 2
yearProcessed: 2019
countryOfOrigin:
individualCount: 2
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq single cell ATAC-seq
externalRepositoryUri: geo:GSE137069
includedInDataCatalog:

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