GSE132326

syn77070256

Created By Aditya Nath aditya.nath

doi: 10.1038/s41586-020-03147-x
title: An epigenetic program established by gene – environment interactions initiates pancreatic carcinogenesis [Set1]
funder: NIH-NCI
series:
creator: Curbelo Direna Lowe Scott
license: CC-BY 4.0
species: Mus musculus
studyId: syn7315805
subject:
ageGroup:
citation: Alonso-Curbelo D et al. (2021). A gene-environment-induced epigenetic program initiates tumorigenesis. Nature. 590(7847):642-648. doi: 10.1038/s41586-020-03147-x
dataType: gene expression
keywords: pancreas
accessType: Open Access
contributor:
description: Damaged tissues have increased risk of cancer development through poorly understood mechanisms. In the pancreas, tissue damage collaborates with activating mutations in the Kras oncogene to dramatically accelerate the formation of early neoplastic lesions and ultimately pancreatic cancer. By integrating genomics, single-cell chromatin assays and spatiotemporally-controlled functional perturbations in autochthonous mouse models, we show that the combination of Kras mutation and tissue damage p...
grantNumber: CA209975
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE132326
manifestation:
specimenCount: 19
yearProcessed: 2019
countryOfOrigin:
individualCount: 19
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE132326
includedInDataCatalog:

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