GSE136908

syn77068512

Created By Aditya Nath aditya.nath

doi: 10.1161/CIRCULATIONAHA.119.041231
title: RNA Seq of HMVEC under hypoxia
funder: NIH-NCI
series:
creator: Qi Zhijie Zhong Sheng
license: CC-BY 4.0
species: Homo sapiens
studyId: syn22115279
subject:
ageGroup:
citation: Tang X et al. (2020). Suppression of Endothelial AGO1 Promotes Adipose Tissue Browning and Improves Metabolic Dysfunction. Circulation. 142(4):365-379. doi: 10.1161/CIRCULATIONAHA.119.041231
dataType: gene expression
keywords: Passage 3-4
accessType: Open Access
contributor:
description: Purpose: to profile transcriptome changes due to EC-AGO1-deficiency Methods: We had HMVECs subjected to normoxia (20%) or hypoxia (2%) for 0, 12, 24, and 48 hr in biological replicates. Total RNA was extracted with mirVana total RNA isolation kit (Life Technologies). RNA-seq was performed. Results: We found genes involved in pathways promoting angiogenesis, browning, insulin sensitivity to be upregulated, and those promoting inflammation and fibrosis to be decreased in KO compared with WT mic...
grantNumber: CA250046
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE136908
manifestation:
specimenCount: 8
yearProcessed: 2019
countryOfOrigin:
individualCount: 8
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE136908
includedInDataCatalog:

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