GSE103672

syn77068425

Created By Aditya Nath aditya.nath

doi: 10.1073/pnas.1707517114
title: Longitudinal Transcriptional Response of Endothelial Cells to Shear Stress
funder: NIH-NCI
series:
creator: Chen Zhen Subramaniam Shankar Shyy John Chien Shu Maurya Mano Ajami Nassim Gupta Shakti Nguyen Phu Li Julie
license: CC-BY 4.0
species: Homo sapiens
studyId: syn22115279
subject:
ageGroup:
citation: Ajami NE et al. (2017). Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A. 114(41):10990-10995. doi: 10.1073/pnas.1707517114
dataType: gene expression
keywords: Blood vessel HUVEC
accessType: Open Access
contributor:
description: The goal of this study was to find longitudinal transcriptional response of Human Umbilical Vein Endothelial Cells (HUVECs) to pulsatile shear (PS) and oscillatory shear (OS). PS is associated with an atheroprotective endothelial phenotype, while OS is associated with an atheroprone endothelial phenotype. Using RNASeq method (single-ended 50-bp sequencing on Illumina Hi-seq 2000 instrument), we measured the transcriptional response at 10 time-points (1, 2, 3, 4, 6, 9, 12, 16, 20, 24 hr) under...
grantNumber: CA250046
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE103672
manifestation:
specimenCount: 42
yearProcessed: 2017
countryOfOrigin:
individualCount: 42
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE103672
includedInDataCatalog:

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