GSE103224

syn77068011

Created By Aditya Nath aditya.nath

doi: 10.1186/s13073-018-0567-9
title: Single-Cell Transcriptome Analysis of Lineage Diversity and Microenvironment in High-Grade Glioma
funder: NIH-NCI
series:
creator: Yuan Jinzhou Sims Peter Levitin Hanna
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349759
subject:
ageGroup:
citation: Yuan J et al. (2018). Single-cell transcriptome analysis of lineage diversity in high-grade glioma. Genome Med. 10(1):57. doi: 10.1186/s13073-018-0567-9
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Despite extensive molecular characterization, we lack a comprehensive picture of lineage identity, differentiation, and microenvironmental composition in high-grade gliomas (HGGs). We sampled the cellular milieu of HGGs with massively-parallel single-cell RNA-Seq. While HGG cells can resemble glia or even immature neurons and form branched lineage structures, mesenchymal transformation results in unstructured populations. Glioma cells in a subset of mesenchymal tumors lose their neural lineag...
grantNumber: CA193313
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE103224
manifestation:
specimenCount: 8
yearProcessed: 2017
countryOfOrigin:
individualCount: 8
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq single-cell RNA-seq
externalRepositoryUri: geo:GSE103224
includedInDataCatalog:

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