GSE127194

syn77065948

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-021-24951-7
title: Topological isolation as a mechanism for precise control of developmental regulators in mammalian genomes [RNA-seq]
funder: NIH-NCI
series:
creator: Wu Hua-Jun Landshammer Alexandro Meissner Alexander Michor Franziska
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject: ZIP13K2
ageGroup:
citation: Wu HJ et al. (2021). Topological isolation of developmental regulators in mammalian genomes. Nat Commun. 12(1):4897. doi: 10.1038/s41467-021-24951-7
dataType: gene expression
keywords: ZIP13K2
accessType: Open Access
contributor:
description: Recent investigation of insulated chromosome structures suggests their crucial role in controlling proper gene expression. However, it remains unclear whether developmental regulators can be precisely controlled by such insulated structures and whether developmental failure is caused by disrupting the structure boundaries. Here we identified topologically insulated regions (TIRs) from deeply sequenced human embryonic stem cell (hESC) Hi-C data and analyzed the gene distribution across TIRs. W...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE127194
manifestation:
specimenCount: 21
yearProcessed: 2019
countryOfOrigin:
individualCount: 21
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE127194
includedInDataCatalog:

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