GSE130085

syn77065774

Created By Aditya Nath aditya.nath

doi: 10.1038/s41467-021-24951-7
title: Topological isolation as a mechanism for precise control of developmental regulators in mammalian genomes [HiC]
funder: NIH-NCI
series:
creator: Wu Hua-Jun Landshammer Alexandro Meissner Alexander Michor Franziska
license: CC-BY 4.0
species: Homo sapiens
studyId: syn7349757
subject:
ageGroup:
citation: Wu HJ et al. (2021). Topological isolation of developmental regulators in mammalian genomes. Nat Commun. 12(1):4897. doi: 10.1038/s41467-021-24951-7
dataType: chromatin activity
keywords:
accessType: Open Access
contributor:
description: Developmental regulators are spatiotemporal regulated in the process of human development. Recent investigation of insulated chromosome structures suggests their crucial role in control of proper gene expression. However, it’s unclear whether developmental regulators can be precisely controlled by such insulated structures and whether developmental failure can be caused by disrupting the structure boundaries. Here we identified topologically insulated regions (TIRs) from deeply sequenced huma...
grantNumber: CA193461
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE130085
manifestation:
specimenCount: 17
yearProcessed: 2019
countryOfOrigin:
individualCount: 17
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: HI-C
externalRepositoryUri: geo:GSE130085
includedInDataCatalog:

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