GSE130236

syn77063783

Created By Aditya Nath aditya.nath

doi:
title: Disrupting ß-catenin dependent Wnt signaling activates an invasive gene program predictive of colon cancer progression
funder: NIH-NCI
series:
creator: Waterman Marian Mortazavi Ali Edwards Robert Chen George Murad Rabi Tifrea Delia Lyou Yung
license: CC-BY 4.0
species: Homo sapiens Mus musculus
studyId: syn18145018
subject:
ageGroup:
citation:
dataType: gene expression
keywords: caecum
accessType: Open Access
contributor:
description: The recent classification of colon cancer into molecular subtypes revealed that patients with the poorest prognosis harbor tumors with the lowest levels of Wnt signaling. This is contrary to the long-standing understanding that overactive Wnt signaling promotes tumor progression from early initiation stages through to the later stages including invasion and metastasis. Here, we lower the levels of Wnt signaling in SW480 and SW620 colon cancer cell lines via interference with two different ste...
grantNumber: CA217378
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE130236
manifestation:
specimenCount: 21
yearProcessed: 2019
countryOfOrigin:
individualCount: 21
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: RNA-seq
externalRepositoryUri: geo:GSE130236
includedInDataCatalog:

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