GSE135412

syn77060780

Created By Aditya Nath aditya.nath

doi: 10.1016/j.celrep.2021.110220
title: Single-cell analysis of accessible chromatin in human mammary epithelial cells using scATAC-seq [scATAC-seq]
funder: NIH-NCI
series:
creator: Kusi Meena Mitsuya Kohzoh Huang Tim
license: CC-BY 4.0
species: Homo sapiens
studyId: syn9773346
subject:
ageGroup:
citation: Kusi M et al. (2022). 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity. Cell Rep. 38(2):110220. doi: 10.1016/j.celrep.2021.110220
dataType: chromatin activity
keywords: Primary mammary epithelial cells
accessType: Open Access
contributor:
description: Epigenome delineates lineage-specific transcriptional programs and restricts cell plasticity to prevent non-physiological cell fate transitions. Although cell diversification fosters tumor evolution and therapy resistance, upstream mechanisms that regulate the stability and plasticity of cancer epigenome remain elusive. Here, we show that 2-hydroxyglutarate (2HG) not only suppresses DNA repair but also mediates high-plasticity chromatin landscape. A combination of single-cell epigenomic and m...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE135412
manifestation:
specimenCount: 288
yearProcessed: 2019
countryOfOrigin:
individualCount: 288
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ATAC-seq single cell ATAC-seq
externalRepositoryUri: geo:GSE135412
includedInDataCatalog:

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