GSE127894

syn77054490

Created By Aditya Nath aditya.nath

doi: 10.1093/nar/gkac246
title: Phosphorylated MED1 Links Transcription Recycling and Cancer Growth
funder: NIH-NCI
series:
creator: Chen Zhong Ye Zhenqing
license: CC-BY 4.0
species: Homo sapiens Mus musculus
studyId: syn9773346
subject:
ageGroup:
citation: Chen Z et al. (2022). Phosphorylated MED1 links transcription recycling and cancer growth. Nucleic Acids Res. 50(8):4450-4463. doi: 10.1093/nar/gkac246
dataType: chromatin activity gene expression
keywords:
accessType: Open Access
contributor:
description: Mammalian RNA polymerase II (Pol II) initiation, elongation, termination and reinitiation are well studied, but how Pol II dynamically recycles after the transcription cycle remains unclear. By establishing in vitro and in vivo transcription recycling systems, we find that human Mediator 1 (MED1), when phosphorylated at the mammal-specific threonine 1032 by cyclin-dependent kinase 9, dynamically travels with Pol II throughout the transcribed genes to drive Pol II recycling. Mechanistically, M...
grantNumber: CA217297
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE127894
manifestation:
specimenCount: 42
yearProcessed: 2019
countryOfOrigin:
individualCount: 42
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: ChIP-seq RNA-seq
externalRepositoryUri: geo:GSE127894
includedInDataCatalog:

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