GSE134856

syn77050011

Created By Aditya Nath aditya.nath

doi: 10.1016/j.isci.2022.104599
title: Viral Mimicry by Endogenous Y-RNAs Contributes to Antiviral Immunity [DV-4]
funder: NIH-NCI
series:
creator: VABRET Nicolas NAJBURG Valérie SOLOVYOV Alexander ŠULC Petr BALAN Sreekumar BEAUCLAIR Guillaume CHAZAL Maxime VARET Hugo LEGENDRE Rachel SISMEIRO Odile DAVID Raul McCLAIN Christopher GOPAL Ramya CHAUVEAU Lise SCHWARTZ Olivier JOUVENET Nolwenn MARKOWITZ Martin TANGY Frédéric BHARDWAJ Nina GREENBAUM Benjamin KOMAROVA Anastasia
license: CC-BY 4.0
species: Homo sapiens
studyId: syn32405996
subject:
ageGroup:
citation: Vabret N et al. (2022). Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1. iScience. 25(7):104599. doi: 10.1016/j.isci.2022.104599
dataType: gene expression
keywords:
accessType: Open Access
contributor:
description: Pattern recognition receptors (PRRs) protect against host invasion by detecting specific molecular patterns found in pathogens and initiating an immune response. While microbial-derived PRR ligands have been extensively characterized, the contribution and relevance of endogenous ligands to PRR activation during viral infection remain overlooked. In this work, we characterize the landscape of endogenous ligands that engage RIG-I-like receptors upon infection by a positive-sense RNA virus, a ne...
grantNumber: CA228963
diseaseFocus:
downloadType: Synapse Hosted
alternateName: GSE134856
manifestation:
specimenCount: 18
yearProcessed: 2019
countryOfOrigin:
individualCount: 18
visualizeDataOn:
dataUseModifiers:
conditionsOfAccess: No restriction
measurementTechnique: flow cytometry RNA-seq quantitative PCR western blot
externalRepositoryUri: geo:GSE134856
includedInDataCatalog:

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