Hi all, I have a question regarding the expected topological connectivity of the compounds in the DEL library. Based on standard tri-building block DEL synthesis designs, the assumption is often that BB1 serves as a scaffold, BB2 acts as a linker/core reacting with BB1, and BB3 subsequently reacts with BB2—resulting in a linear BB1–BB2–BB3 connection pattern. However, reviewing the example diagram on the challenge wiki ([DEL Synthesis - Important concepts](https://www.synapse.org/Synapse:syn75349604/wiki/641133)), BB3 appears to react directly with BB1 rather than BB2. Could you clarify the connectivity rules across the dataset? Specifically: 1. Are BB1 and BB3 strictly separated by BB2 in all library members, or are there sub-libraries/reaction schemes where BB3 connects directly to BB1? 2. Should we rely exclusively on the enumerated SMILES to establish connectivity, or does the wiki diagram reflect a specific alternative topology present in the library? Thanks in advance for your guidance!