Hello GENIE team, I am working with the `genomic_information` file and I'm having some trouble understanding the `includeInPanel` column. My understanding is that the `genomic_information` file contains all of the regions sequenced in each panel from each participating center. I do not understand what circumstances result in a region being labeled as `includeInPanel=False`. Were these regions sequenced, but not used downstream? Apologies for the very basic question, and thank you in advance!

Created by Dylan Taylor dylan.taylor
Hi @chelsea.nayan, Thank you so much for the response and guidance! I've also been working with the [TMB estimates from the 19.0 release](https://www.synapse.org/Synapse:syn72382879), and it looks like these estimates might include the `includeInPanel=False` regions in this calculation. If I'm understanding correctly, your response suggests these regions should NOT be considered when calculating TMB, is that correct? Thank you again and apologies if I'm misunderstanding!
Hi @dylan.taylor, This is a great question and there has been some discussion around this variable. The includeInPanel variable indicates whether a gene/region is intended to be part of the panel for analysis, as defined by the submitting center. Regions marked False may still appear in the file, but are not considered part of the effective panel and should not be used to define panel coverage or whether a gene was assayed.

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