A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity

syn71964948

Community Contributed publication dataset from Manuel Garber and John E. Harris of the University of Massachusetts Chan Medical School Vitiligo Center of Research Translation (V-CoRT). Using a variety of investigational methods the authors examined in vivo and in vitro samples to investigate an interferon-I (IFN-I)-amplified skin pathology and identified MMP9+ CD14+ myeloid cells as central effectors of photosensitivity in both cutaneous lupus erythematosus and dermatomyositis.
Created By Jessica Vera jmvera

doi: 10.7303/syn71964948.1
assay: NULISA Olink Flex scRNASeq GenePS SeqFISH RNASeq
program: Community Contribution
project: UMass V-CoRT
species: Homo sapiens
dataType: proteomics transcriptomics
diagnosis: CLE dermatomyositis psoriasis vitiligo control
ARKRelease: 2026.02.R1
dataSubtype: single-cell spatial bulk
datasetType: publication
datasetStatus: released
biospecimenType: suction blister fluid primary cell culture suction blister cells skin biopsy
publicationSynID: syn72124011
biospecimenSubtype: supernatant cell suspension frozen tissue
datasetDescription: syn71748916
acknowledgmentStatement: syn26710600/wiki/637261

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