RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

syn68932658

N6-methyladenosine (m6A) regulates TDP43–RNA interactions in ALS, with widespread hypermethylation and m6A regulators shaping neurodegeneration
Created By Ram Ayyala ram.ayyala

url: https://www.ncbi.nlm.nih.gov/bioproject/PRJNA912644
assay: RNA-seq
title: RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia
sameAs: srp:SRP413231
source: Sequencing Read Archive
disease: ALS
license: public
species: Homo sapiens
cellType: HEK293T
dataType: transcriptomics
keywords: RNA-seq APOBEC Halo HEK293T treatment cell line
studyType: experimental study
collection: National Institutes of Health
contributor: Barmada Lab - University of Michigan
libraryLayout: paired-end
portalRelease: 2025.1
biospecimenType: primary cell culture
individualCount: 9
acknowledgementStatement: syn64892175/wiki/634029

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