Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS - Retrotransposon Activation, Oxidative Stress, and Activated Glia

syn67737779

Gene Expression Omnibus RNA-seq dataset profiling brain tissue samples from frontal cortex, medial motor cortex, lateral motor cortex, and motor cortex collected from ALS, FTD, Control, Pre-fALS, Alzheimer's Disease, Other Neurological Disorders, and Other Motor Neuron Disease cases.
Created By Aditya Nath aditya.nath

url: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124439
assay: RNA-seq
sameAs: geo:GSE124439
source: Gene Expression Omnibus
disease: ALS FTD Control Pre-fALS Alzheimer's Disease Other Neurological Disorders Other Motor Neuron Disease
species: Homo sapiens
dataType: transcriptomics
keywords: Alzheimer's Disease Other Neurological Disorders Other Motor Neuron Disease Frontotemporal Dementia Amyotrophic Lateral Sclerosis brain tissue RNA-seq transcriptomics post-mortem tissue
CNSRegion: frontal cortex medial motor cortex lateral motor cortex motor cortex
studyType: experimental study
contributor: NYGC ALS Consortium Target ALS
dataSubtype: bulk
isPostMortem: True Unknown
libraryLayout: paired-end
portalRelease: 2025.1
GEOSuperSeries: GSE137810
biospecimenType: brain tissue
individualCount: 95
acknowledgementStatement: syn64892175/wiki/633970
libraryPreparationMethod: KAPA Stranded RNA-Seq Kit with RiboErase

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