Dear @CAGI7ChallengesParticipants , join us in Boston for the 7th round of CAGI conferences. The CAGI7 Conference [https://genomeinterpretation.org/cagi7.html] will take place on the campus of Northeastern University in Boston from December 6-8, 2025. **Registrations are open!** Abstract submissions remain open! Limited NIH **fellowships** are available for students, post-docs, and research staff. Confirmed Keynotes: Doug Fowler, University of Washington Heidi Rehm, Broad Institute of MIT and Harvard Confirmed Invited Speakers (incomplete): Michael Beer, Johns Hopkins University Kinga Bujakowska, Harvard Medical School Emidio Capriotti, University of Bologna Sung Chun, Harvard Medical School Sven Diederichs, Albert-Ludwigs-University Freiburg and German Cancer Consortium Michael Gelb, University of Washington Nilah Ioannidis, UC Berkeley Jennifer Lin, UC Berkeley Joe Marsh, University of Edinburgh Vikas Pejaver, Mount Sinai School of Medicine Fritz Roth, University of Pittsburgh Doug Speed, Aarhus University Dean Suhr, MLD Foundation Shamil Sunyaev, Harvard Medical School Lea Starita, University of Washington This year’s conference will feature assessments on multiple challenges from the CAGI7 season, including TSC2, BARD1, ATP7B, LPL, FGFR, lentiMPRA, Splicing Mini Gene, and Polygenic Risk Score. The Rare Genomes Project (RGP) challenge remains ongoing in an off-cycle manner (a great time to participate in it). A tentative program will be posted soon on our web site. **The CAGI7 Special Papers Collection will be organized after the conference and the completion of RGP and Annotate-All challenges.** Questions? Feel free to email us at cagi@genomeinterpretation.org