methods: syn68876311 project: NECS species: Human studyKey: NECS_supercentenarians studyName: The New England Centenarian Study (NECS) studyWiki: syn53269925 accessReqs: syn27229419/wiki/631202 ackContext: syn27229419/wiki/622005 consortium: ELITE dataStatus: Available isReleased: true studyFocus: Longevity dataTypeAll: Gene Expression Clinical metadataType: study studyAbstract: Supercentenarians (110+ years) often avoid age-related diseases well past 100, likely due to genetic factors. We sequenced genomes of two individuals aged >114, finding: variant profiles similar to typical genomes, absence of most known longevity variants, ~1% novel variants, and enrichment for new longevity-linked variants. These findings suggest both common and rare variants help maintain health in extreme old age. studyMetadata: syn68899990 acknowledgment: syn68876295 dataRestriction: Not Applicable studyDescription: syn53269925 syn68876295 syn68876294 syn68899990 syn68876311