Granzyme K+ CD8 T cells form a core population in inflamed human tissue

syn29837062

Using data from the AMP RA Immune Repertoire Profiling dataset, synovial tissue and synovial fluid CD8+ T cells were found to be predominated by a population of effector CD8+ T cells characterized by high expression of granzyme K and low expression of granzyme B and perforin as described in Science Translational Medicine https://doi.org/10.1126/scitranslmed.abo0686.
Created By Mette Peters Mette

assay: scVDJSeq scRNASeq
program: AMP RA/SLE
project: RA
dataType: immune repertoire profiling transcriptomics
diagnosis: RA
ARKRelease: 1.0
dataSubtype: single-cell
datasetType: publication
programPhase: II
biospecimenType: PBMCs
publicationSynID: syn64429477
associatedCodeURL: https://github.com/immunogenomics/TteK/tree/main
associatedDataset: syn47090942
libraryPrepMethod: 10x Chromium Next GEM Single Cell 5' v1.1
datasetDescription: syn47265559
acknowledgmentStatement: syn26710600/wiki/619685

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