grant: U24AG051129 Authors: methods: syn26128990 program: ELITE project: LG species: Human studyKey: MRGWAS studyName: The Mendelian Randomization of Human Longevity Using Genetically-Predicted Exposures from the GWAS Catalog (MRGWAS) Study studyType: Individual studyWiki: syn26066886 accessReqs: syn27229419/wiki/630337 ackContext: syn27229419/wiki/622005 consortium: ELITE dataStatus: Available isFeatured: false isReleased: true studyFocus: Longevity contributor: dataTypeAll: Genomic Variants metadataType: study resourceType: metadata specimenType: Blood isModelSystem: false studyAbstract: This study used Two Sample Mendelian Randomization (2SMR) on 4,112 GWAS traits and five definitions of longevity to identify 685 significant associations. Findings highlight negative links between cancer, obesity, Type 2 diabetes and longevity, and positive roles for cardiovascular health. Results provide candidate mechanisms and intervention targets for healthy aging. studyMetadata: syn27229419/wiki/623142 acknowledgment: syn27229419/wiki/621603 relatedStudies: syn26969078 syn26720399 syn53404403 dataContributor: California Pacific Medical Center Buck Institute for Research on Aging Translational Genomics Research Institute University of California San Francisco dataRestriction: Registered studyDescription: syn26066886 syn26066895 syn26340306 syn56859789