Hello,
In the metadata file of syn23277389, the information of Braak stage and thal level have been provided, however still there is no information for apart of samples. And also the CERAD level is not provided there. I was wondering is there any chance to have access to the missing data? Specifically about CERAD. It is somehow impossible to determine AD stage (early, intermediate, late) without having this information.
Best,
Tima
Created by Fatemeh Zebardast Timaa.z Hi Tima,
Unfortunately the CERAD scores were not provided per individual in the metadata file for this study, but the following information on diagnosis criteria is available from the study description:
>Within this cohort, all AD and PSP subjects were from the Mayo Clinic Brain Bank (MCBB), and all PA subjects were obtained from the Banner Sun Health Research Institute (Banner). Thirty-four control CBE and 31 control TCX samples were from the MCBB, and the remaining control tissue was from Banner. All subjects selected from the MCBB and Banner underwent neuropathologic evaluation by Dr. Dennis Dickson or Dr. Thomas Beach, respectively. All ADs had definite diagnosis according to the NINCDS-ADRDA criteria and had Braak NFT stage of IV or greater. Control subjects had Braak NFT stage of III or less, CERAD neuritic and cortical plaque densities of 0 (none) or 1 (sparse) and lacked any of the following pathologic diagnoses: AD, Parkinson?s disease (PD), DLB, VaD, PSP, motor neuron disease (MND), CBD, Pick?s disease (PiD), Huntington?s disease (HD), FTLD, hippocampal sclerosis (HipScl) or dementia lacking distinctive histology (DLDH). Subjects with PA also lacked the above diagnoses and had Braak NFT stage of III or less, but had CERAD neuritic and cortical plaque densities of 2 or more. None of the PA subjects had a clinical diagnosis of dementia or mild cognitive impairment.
For more information on the study cohort, you could try contacting Dr. Nilüfer Ertekin-Taner at the Mayo Clinic.
Best,
Abby
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