In the Mayo cohort, there are 41 samples described as having 'pathological diagnosis of pathologic aging' (syn7344223). I was wondering how this diagnosis was made, via imaging or post-mortem? If the latter, what thresholds of plaque and tau levels did they need to reach? Is there any consensus over whether these samples are likely to be resilient despite pathology _or_ whether they are the beginning stages of AD and would likely get symptoms if they had lived longer?
Created by Sarah Morgan SarahMog The PA diagnosis was made based on pathology. This paper and references therein has more information about the data and diagnosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058336/