Thanks for the great AD data/resource. I have several questions regarding several studies: For these two multiomic AD studies ([Xiong et al](https://www.cell.com/cell/fulltext/S0092-8674(23)00974-1) and ([Liu et al](https://www.cell.com/cell/fulltext/S0092-8674(25)00733-0) I was looking to access the sc/snRNA-seq and snATAC-seq corresponding to their studies. I saw that their data is deposited here (for Xiong et al, snATAC https://www.synapse.org/Synapse:syn66271521 and snMultiome https://www.synapse.org/Synapse:syn66271522, and for Liu et al, https://www.synapse.org/#!Synapse:syn52293417). For both studies, it seems there are multiple possorted\_bam.bam/fragments.tsv.gz that appear to correspond to different subsets (donor or tissue?) of the data (e.g. D19-122585.fragments.tsv.gz or 231019KelA\_AG3.gex\_possorted\_bam.bam). For these two studies, I was wondering, if there is preprocessed .h5ad or .h5mu (or something similar) files available, for both RNA/ATAC/multiome, that I can use to directly read in without combining multiple bam/fragment files? If not, are there any ROSMAP multiome/RNA+ATAC studies with processed h5ad/h5mu that I can directly use? Thanks in advance for the help and support. -Patrick

Created by Patrick Yu patricky

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