Hi there, I am trying to map the pathology metadata of the 427 participants selected by the MIT_ROSMAP study with the Seurat object that the group used in the" Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology." Specifically, I would like to access the pathology information, such as overall amyloid level, plaque burden, tangle density, and clinical cognitive phenotype etc. Does anyone know where I could find these metadata? Best, Xiangyu

Created by Xiangyu Liao xiangyu_liao
Hello @xiangyu_liao, Sorry for the late response. I believe the file that you are looking for is syn3191087, which contains the clinical/pathological values for Rosmap donors. You will likely need to map the specimenIDs in this dataset to the projids in the clinical file using the metadata that is available in https://www.synapse.org/Synapse:syn52293430. Let me know if you have any trouble with that or don't see the correct mappings needed. Best, Will

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