Hello, **I am curious how sex and/or gender were defined for the ROSMAP study (syn16780177 specifically) and if these are consistent across studies?** Since sex and/or gender are both not binary, but are represented by constructed, binary categories, I am also wondering if the team can provide us with specific sexual traits metadata that may better inform our hypotheses and analyses on sex differences in Alzheimer's disease (AD)? For example, categorical sex is not sufficient to explain disease alone, however if we look at a specific sexual trait like chromosomal organization, we can generate clear hypotheses about the influence of XX chromosomes on disease prevalence. Can someone please share the following at your earliest convenience? **1. Were the chromosomes of these patients assessed? Are all individuals XX or XY? ** **2. Were hormone levels assessed? Is this data available? ** 3. Was adiposity assessed? Obesity is associated with metabolic diseases like AD, so this should be a critical piece to include for future analyses as well.