MSKCC Driver Genes

Created By Kyle Ellrott kellrott
Field | Description ------------|------------------- TS/OG | original annotations as tumor suppressor (1) or oncogene (2) or both (3) or neither (0); CG | total number of cancer annotations CancerTypes | cancer names where a gene is mutated Cancers | number of cancers where a gene is mutated Samples | total number of samples in cancers where a gene is mutated Index | sum of indexes "Func", "FuncD/A", "CNA", "TopCG" Total | Sum of high-scoring functional and truncating mutations, homozygous deletons and amplifications TS | predicted tumor suppressor OG | predicted oncogene Func | index of significant over-presence of predicted high-scoring functional mutations and truncating mutations versus low-functional mutations FuncD/A | index of significant co-occurrence of predicted functional mutations or truncating mutations in regions of copy loss or copy gain CNA | index of significant over-presence of homozygous deletions versus amplifications or vice verse. TopCG | index of top cancer genes (annotated TS or OG in column TS/OG ; or four or more cancer annotations in column CG) MM | total number of missense mutations TM | total number of truncating mutations stop/non-stop codons; indels; splice sites) SM | total number of silent mutations FIS>=2.0 | total number of predicted functional missense mutations FIS>=2.5 | total number of predicted high-scoring functional mutations HFTM_Top_CG | index of "top cancer genes" affected by high-scoring of truncating mutations DD | total numeber of homozygous deletions DTFM | total number of hemezygous deletions affected by functional or truncating mutations AA | total number of amplifications AFM | total number of copy gains affected by functional mutations D_TFM | number of cancer types with significant co-occurance of truncating and functional mutations in regions of copy loss D_TFM Cancers | cancer types with significant co-occurance of truncating and functional mutations in regions of copy loss A_FM | number of cancer types with significant co-occurance of functional mutations in regions of copy gain A_FM Cancers | cancer types with significant co-occurance of functional mutations in regions of copy gain HFTM >> LFM | number of cancer types with significant over-presense of predicted high-scoring functional mutations HFTM >> LFM Cancers | cancer types with significant over-presense of predicted high-scoring functional mutations DD>>AA | number of cancer types with significant over-presense of homozygous deletions versus amplifications DD>>AA Cancers | cancer types with significant over-presense of homozygous deletions versus amplifications AA>>DD | number of cancers types with significant over-presense of amplifications versus homozygous deletions AA>>DD Cancers | cancers types with significant over-presense of amplifications versus homozygous deletions

syn1720071
syn1720073