I am a Post-doctoral Research Fellow in Centre for Genetic Medicine Research at Childrens' National Hospital. Under supervision from Prof Javad Nazarian and Dr Miriam Bornhost, we are establishing in-vitro and in-vivo CRISPR-Knockout models targeting on multiple molecular oncogenic markers, including NF1, CDKN2a, ATRX, and MTAP. The generated CRISPR models will served as preclinical tools in investigating the tumour transformation of NF1 low Grade Glioma into High Grade Glioma. My research has utilized clinically relevant preclinical models including cell xenograft, patient-derived xenograft and genetically engineered mouse models of cancer. In addition, I have utilized state-of-the-art molecular techniques including CRISPR/Cas9, high throughput drug screening, ATAC-seq and RNA-seq, as well as extensive cell culture and other robust in-vitro assays.